Long‐term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans

Peter Kokkinos; Yan Cheng; Edward Zamrini; Charles Faselis; Xuemei Sui; Charity J. Morgan; Helen Sheriff; Jonathan A. Myers; Barry A. Franklin; Brandon L. Alderman; Qing Zeng‐Treitler

doi:10.1002/trc2.70171

October 1, 2025Alzheimer s & Dementia Translational Research & Clinical InterventionsOpen Access

Long‐term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate the association between longitudinal changes in cardiorespiratory fitness and the subsequent incidence of Alzheimer's disease and related dementias.
Retrospective cohort analysis of US Veterans (N = 5,421) who underwent two standardized exercise treadmill tests at least 1 year apart (mean 3.5 ± 2.7 years) between 2000 and 2017.
Participants were free of dementia at baseline and categorized by peak metabolic equivalents (METs) achieved initially (3 categories) and fitness change over time (5 categories).
Multivariable Cox proportional hazards models adjusted for age, comorbidities, and medications were used to assess dementia risk.
Longitudinal changes in cardiorespiratory fitness demonstrated an inverse, independent, and proportional association with dementia risk (p < 0.0001).
Low-fit individuals who improved cardiorespiratory fitness by ≥0.1 METs experienced a 13% to 24% reduction in ADRD risk.
A cardiorespiratory fitness decline of ≥2.0 METs was associated with a 14% increased ADRD risk in moderate-fit individuals and an 18% increased risk in high-fit individuals.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Cohort study demonstrates an inverse association between cardiorespiratory fitness changes and dementia risk in US veterans, indicating fitness improvements may protect cognitive health.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kokkinos et al. (2025) studied this question.

synapsesocial.com/papers/69f14b1d2811130d0cde202b https://doi.org/10.1002/trc2.70171

View Full Paper

Ask AI

Bookmark

Share

Long‐term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Long‐term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading