Why the study?
Does intravascular ultrasound imaging accurately characterize tissue and quantify lumen and atheroma areas in human coronary arteries compared to histology and angiography?
Population
27 patients after coronary balloon angioplasty, and 20 human atherosclerotic artery segments in vitro
Comparison
Intravascular ultrasound imaging using a 20-MHz… vs In vitro histological preparations and angiography
Design
Cross-sectional
Authors
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IVUS detects substantial residual and occult atheroma missed by angiography; leaves open whether IVUS guidance improves revascularization outcomes.
Does intravascular ultrasound imaging accurately characterize tissue and quantify lumen and atheroma areas in human coronary arteries compared to histology and angiography?
Intravascular ultrasound is more sensitive than angiography for detecting atherosclerosis and reveals significant residual atheroma after balloon angioplasty.
Tobis et al. (1991) studied this question.