Why the study?
Does reperfusion after 6 hours of coronary occlusion cause myocardial hemorrhage in anesthetized dogs?
Population
38 anesthetized dogs
Comparison
Reperfusion after 6 hours of circumflex coronary… vs Control occlusion with no reperfusion
Design
Preclinical
Follow-up
24 hours
Authors
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Reperfusion hemorrhage signals severe pre-existing necrosis in dogs; leaves open whether it causes new damage in viable human myocardium.
Does reperfusion after 6 hours of coronary occlusion cause myocardial hemorrhage in anesthetized dogs?
Myocardial hemorrhage following reperfusion is a consequence of severe pre-existing ischemic necrosis rather than an independent cause of new damage in otherwise viable tissue.
Higginson et al. (1982) studied this question.
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