Long QT syndrome: beyond the causal mutation
Population
Patients with congenital long QT syndrome (LQTS) and heterozygous mutation carriers
Design
Review
Authors
Discussion
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Implication
Supports incorporating modifiers into LQTS risk models; leaves open prospective trials to confirm impact.
Structured PICO
P
Population
Patients with congenital long QT syndrome (LQTS) and heterozygous mutation carriers
Clinical outcomes in congenital long QT syndrome are not solely determined by the primary causal mutation, but are significantly influenced by additional demographic, environmental, and genetic modifying factors.
Cite This Study
Amin et al. (2013) studied this question.