Key result
Each 1-MET increase in VO2peak linked to ~18% lower coronary death risk in healthy men.
Why the study?
Few data exist on whether the prognostic value of peak exercise oxygen consumption (VO2peak) for fatal and non-fatal coronary events differs among men with low and high pre-test probability for cardiovascular disease.
Does higher cardiorespiratory fitness (VO2peak) predict a lower risk of fatal and non-fatal cardiac events in men aged 42-60 years regardless of baseline CVD risk?
Population
2361 men aged 42-60 years with and without conventional CVD risk predictors or documented CVD
Comparison
Higher versus lower VO2peak levels
Design
Prospective population-based cohort study
Follow-up
13 years
Authors
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Reinforces VO2peak for risk stratification in middle-aged men; extends prior associations across risk strata but remains hypothesis-generating.
Cohort (n=2,361)
Does higher cardiorespiratory fitness (VO2peak) predict a lower risk of fatal and non-fatal cardiac events in men aged 42-60 years regardless of baseline CVD risk?
Relative Risk: 0.82 (95% CI 0.66–0.99)
Higher cardiorespiratory fitness (VO2peak) is a strong, independent predictor of reduced fatal and non-fatal cardiac events in middle-aged men, regardless of baseline cardiovascular risk profile.
Laukkanen et al. (2004) conducted a cohort in Cardiovascular disease (n=2,361). Peak exercise oxygen consumption (VO2peak) vs. Lower VO2peak was evaluated on Coronary death (per 1 MET increment in healthy men) (RR 0.82, 95% CI 0.66-0.99). A 1-MET increment in peak exercise oxygen consumption (VO2peak) decreased the risk of coronary death in healthy (RR 0.82; 95% CI 0.66-0.99) and unhealthy (RR 0.72; 95% CI 0.63-0.82) men.
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