Ionic Mechanisms Responsible for the Electrocardiographic Phenotype of the Brugada Syndrome Are Temperature Dependent
Population
Mammalian cell line expressing the Thr1620Met missense mutation in the SCN5A gene
Comparison
Patch-clamp technique at 32 degrees C vs Wild type sodium channel at 32 degrees C
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May warrant fever precautions in Brugada syndrome; leaves open clinical translation from animal models.
Structured PICO
P
Population
Mammalian cell line expressing the Thr1620Met missense mutation in the SCN5A gene
I
Intervention
Patch-clamp technique at 32 degrees C
C
Comparator
Wild type sodium channel at 32 degrees C
O
Outcome
Sodium channel gating characteristics (current decay kinetics, recovery from inactivation, steady-state activation)surrogate
The arrhythmogenicity of the Thr1620Met mutation in Brugada syndrome is temperature-dependent, suggesting increased risk during febrile states.
Cite This Study
Dumaine et al. (1999) studied this question.