What are the outcomes and factors associated with in-hospital mortality for medical versus surgical strategies in adult patients with prosthetic valve endocarditis managed by a multidisciplinary team?
Individualized treatment guided by a multidisciplinary team is associated with favorable short-term outcomes in prosthetic valve endocarditis, and medical therapy may be a safe alternative in selected patients without surgical indications.
Background: Prosthetic valve endocarditis (PVE) is a serious complication of valve replacement associated with significant morbidity and mortality. However, outcomes for medical vs surgical strategies remain incompletely characterized. Methods: We conducted a retrospective cohort study of adult patients with PVE, defined by modified Duke criteria, evaluated by a multidisciplinary endocarditis team at a tertiary-care centre between September 2021 and February 2024. Demographic, clinical, management, and outcome data were collected. Logistic regression analyses were performed to identify factors associated with in-hospital mortality. Results: = 0.97). Conclusions: In this cohort of patients with PVE, individualized treatment guided by a multidisciplinary team was associated with favourable short-term outcomes. Medical therapy may be a safe alternative in selected patients without surgical indications. Early identification of acute renal dysfunction may assist in prognostication and inform management decisions.
Collis et al. (Sat,) studied this question.
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