What question did this study set out to answer?

To measure the dynamic time differences between blood glucose and interstitial glucose using subcutaneous continuous glucose sensors in patients with type 1 diabetes.

November 1, 2003DiabetesOpen Access

Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor

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To measure the dynamic time differences between blood glucose and interstitial glucose using subcutaneous continuous glucose sensors in patients with type 1 diabetes.
Enrolled 14 patients with type 1 diabetes, each equipped with two abdominal subcutaneous continuous glucose monitors (Medtronic/MiniMed CGMS) sampling every 5 minutes.
Collected venous blood glucose every 5 minutes over an 8-hour period during which two liquid meals were administered.
Applied a smoothing algorithm and evaluated first derivatives across 24 datasets to determine the timing of glucose rises, peaks, falls, and nadirs.
Time differences between blood and interstitial glucose ranged from 4 to 10 minutes, with interstitial glucose lagging behind blood glucose in 81% of cases (95% CI, 72.5% to 89.5%).
The mean (±SD) difference between paired sensors within individual patients was 6.7 ± 5.1 minutes, demonstrating substantial random sensor-to-sensor variation.

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Implication

Clinical study reveals interstitial glucose lags behind venous blood glucose in type 1 diabetes, indicating substantial sensor variation during glycemic shifts.

Cite This Study

Boyne et al. (2003) studied this question.

synapsesocial.com/papers/69f14cb0c0d8017361865e71 https://doi.org/10.2337/diabetes.52.11.2790

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Implication

Clinical study reveals interstitial glucose lags behind venous blood glucose in type 1 diabetes, indicating substantial sensor variation during glycemic shifts.

Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor

Key Points

Discussion

Implication

Cite This Study

Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor

Key Points

Discussion

Implication

Cite This Study

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