Why the study?
Do chronic infections and inflammation increase the risk of coronary heart disease in a primary prevention cohort?
Population
482 subjects from the Helsinki Heart Study, consisting of 241 cases who suffered myocardial infarction or…
Comparison
High baseline levels of C-reactive protein and… vs Low antibody levels and low CRP
Design
Case-control
Follow-up
8.5 years
Authors
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Does not support clinical testing or treatment; leaves open causal confirmation in prospective cohorts.
Do chronic infections and inflammation increase the risk of coronary heart disease in a primary prevention cohort?
Chronic infections with HSV-1 and C. pneumoniae, particularly when accompanied by systemic inflammation (elevated CRP), significantly increase the risk of coronary heart disease.
Roivainen et al. (2000) studied this question.
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