Abstract Introduction Application of pit and fissure sealants is among the most effective methods of preventing dental caries. Despite their extensive use, the chemical composition of resin-based sealants is ambiguous and inconsistent. The presented integrative review analytically evaluates the composition of commercially available resin-based dental pit and fissure sealants. Data and sources Targeted searches were conducted between June 1 and November 15, 2025, using PubMed, ScienceDirect, Scopus, alongside general and academic search engines such as Google Scholar, Google. All relevant website entries were saved using the Internet Archive Wayback Machine platform. Study selection Sources providing information on key material components including resin matrix monomers and fillers; grey literature sources and scientific articles published in peer-reviewed journals regarding to the composition of resin-based commercial formulation of dental pit and fissure sealants. Structured data search resulted in identifying 52 formulations of 41 resin-based dental sealants. Among those, 116 unique ingredients were found, of which 41 were assigned a Chemical Abstracts Service number. Conclusions Components were classified according to their function into groups. Cluster analysis allowed for the proposal of a new classification of resin-based dental sealants based on their monomer composition. Three distinctive fluoride forms were identified in the analyzed formulations, with each one resulting in different release kinetics and therapeutic effect (fluoride salts, fluoride glass-ionomer fillers, and fluorinated monomers). Clinical significance The article highlights the significance and clinical importance of each group of identified compounds and aims to increase awareness of the correlation of composition with clinical properties.
Piszko et al. (Thu,) studied this question.
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