Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Renaly I. de A. Rêgo; Hugo F. O. Pires; Arthur L. Dias; Maria Caroline R. B. Remigio; Humberto H. N. de Andrade; Pablo R. da Silva; Natália F. de Sousa; Luciana Scotti; Marcus T. Scotti; Mirian G. S. S. Salvadori; RD CASTRO

doi:10.1002/cbdv.202503228

April 1, 2026Chemistry & BiodiversityOpen Access

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

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Key Points

This study aims to explore the antinociceptive effect of cinnamaldehyde and its mechanisms of action.
In vivo approaches were utilized to assess antinociceptive activity in male mice.
In silico docking simulations were conducted to investigate molecular interactions.
Favorable interactions with κ- and δ-opioid receptors were identified during simulations.
Cinnamaldehyde exhibited acute antinociceptive activity in male mice.
Analysis supports the involvement of κ- and δ-opioid receptors in the antinociceptive effect.

Implication

In vivo tests demonstrate acute antinociceptive activity of cinnamaldehyde in male mice, suggesting involvement of opioid receptors.

Abstract

-adrenergic contribution. Docking simulations showed favorable interactions of CA with κ- and δ-opioid receptors, NMDA, AMPA, and TRPV1, supporting a multimodal mechanism. CA displays acute antinociceptive activity, and the findings suggest the involvement of central pathways, including opioid and adrenergic systems.

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Cite This Study

Rêgo et al. (2026) studied this question.

synapsesocial.com/papers/69f1545d879cb923c4944758 https://doi.org/10.1002/cbdv.202503228

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Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Key Points

Implication

Abstract

Discussion

Cite This Study

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Key Points

Implication

Abstract

Discussion

Cite This Study

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