Design, synthesis, and enzyme kinetic evaluation of oxadiazole derivatives as nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors: an integrated in vitro and in silico approach

Q: What type of study is this?

This is a In Vitro Study study.

Syed Zaighum Abbas; Zaman Ashraf; Sadia Roshan; Kalsoom Sughra; Muhammad Arslan Rahat; Imran Shakir; Muhammad Latif

doi:10.1039/d6ra01543c

January 1, 2026RSC AdvancesOpen Access

Design, synthesis, and enzyme kinetic evaluation of oxadiazole derivatives as nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors: an integrated in vitro and in silico approach

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Key Points

Identify small heterocyclic inhibitors targeting ecto-NTPDases involved in cancer progression and purinergic signaling.
Integrated in vitro and in silico approaches
Enzyme kinetic evaluation of synthesized oxadiazole derivatives
Assessment of their inhibitory effects on NTPDase activity.
Synthesis of multiple oxadiazole derivatives demonstrated potential as NTPDase inhibitors.
Inhibition assays indicated enhanced understanding of ecto-NTPDase roles in cancer progression.
Purinergic signaling pathways were impacted by these newly synthesized compounds.

Implication

Synthesis of oxadiazole derivatives reveals impacts on purinergic signaling in cancer progression, suggesting new therapeutic targets.

Abstract

Overexpression of ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) in cancer progression and purinergic signaling, identification of potential small heterocyclic inhibitors has become a significant objective in medicinal chemistry.

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Cite This Study

Abbas et al. (2026) studied this question.

synapsesocial.com/papers/69f1545d879cb923c49448df https://doi.org/10.1039/d6ra01543c

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Design, synthesis, and enzyme kinetic evaluation of oxadiazole derivatives as nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors: an integrated in vitro and in silico approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, and enzyme kinetic evaluation of oxadiazole derivatives as nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors: an integrated in vitro and in silico approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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