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April 27, 2026Analytical Chemistry

Single-Molecule Dual-Channel NIR Fluorescence Probe for Simultaneous Monitoring ATP and ONOO – during Ferroptosis and Hepatic Ischemia-Reperfusion Injury

Wenxuan Zhang Dechun Li Yushuang Pu Wenjing Jiang Jinping Shao Yutao Li Guoqiang Feng Li Xu Shumin Feng

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Key Points

This research aims to develop a probe for real-time monitoring of ATP and ONOO during ferroptosis and ischemia-reperfusion injury.
Developed a single-molecule dual-channel NIR fluorescence probe
Applied the probe to monitor ATP and ONOO levels
Examined the conditions of ferroptosis and hepatic ischemia-reperfusion injury
Success in simultaneous monitoring of ATP and ONOO
Demonstrated effectiveness in conditions of oxidative stress
Provided insights for further studies on related diseases

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Implication

This probe demonstrates simultaneous monitoring of ATP and ONOO in ferroptosis, suggesting new approaches for oxidative stress-related conditions.

Abstract

in the dynamic monitoring of HIRI and other oxidative stress-related diseases.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69f1547f879cb923c4944b56 https://doi.org/10.1021/acs.analchem.6c00509

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