What question did this study set out to answer?

To evaluate the efficacy and safety of biliary drainage in patients with liver failure from mushroom poisoning.

April 29, 2026Journal of Clinical and Translational Hepatology0 citationsOpen Access

Bile Drainage Improves Survival in Amatoxin-induced Severe Liver Injury: A Prospective Pilot Cohort Study

XMXiuying MaKunming University of Science and Technology BHBin HanFirst People's Hospital of Yunnan Province WYWei YueShenyang Pharmaceutical University

Key Points

To evaluate the efficacy and safety of biliary drainage in patients with liver failure from mushroom poisoning.
Prospective pilot cohort study design
Patients with pre-liver failure due to amatoxin-containing mushroom poisoning
Efficacy and safety of biliary drainage evaluated
Biliary drainage improved survival rates in patients
>50% mortality observed without drainage
Findings suggest potential effectiveness of therapeutic strategy

Abstract

Amatoxin-containing mushroom poisoning causes fatal acute liver failure with >50% mortality despite maximal medical therapy. Interrupting the enterohepatic recirculation of amatoxins is a mechanistically rational but unproven therapeutic strategy. This study aimed to evaluate the efficacy and safety of biliary drainage (BD) in patients with pre-liver failure caused by amatoxin-containing mushroom poisoning.

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