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April 29, 2026European Heart Journal - Imaging Methods and PracticeOpen Access

Submaximal measures of fitness and left ventricular size: associations and utility in differentiating physiological and pathological enlargement

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Authors

JSJulie Stendahl SpetsVSVictoria Elisa Joakimsdatter SørgjerdBNBjarne M. Nes

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Overview

Observational study reveals submaximal fitness measures improve classification of left ventricular size in heart failure, suggesting practical use when peak testing is unfeasible.

Key Points

  • Evaluate the relationship between left ventricular end-diastolic volume and submaximal fitness measures.
  • Participants included 1067 health-survey individuals, 39 recreational athletes, and 53 heart failure patients.
  • Transthoracic echocardiography and cardiopulmonary exercise testing were performed.
  • Pearson’s correlation and linear regression analyzed associations between LVEDV and fitness measures.
  • VO2VT and VO2COP showed better correlation with LVEDV than indexing to body surface area.
  • Indexing LVEDV to submaximal measures identified more heart failure cases than BSA, reducing misclassification.
  • Submaximal measures are comparable to VO2peak in distinguishing left ventricular enlargement.

Cite This Study

Spets et al. (2026) studied this question.

synapsesocial.com/papers/69f154a4879cb923c4944d38https://doi.org/10.1093/ehjimp/qyag081
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Also Consider

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  5. 5Vo2peak, Ve/VCO2, and Cardiac Remodeling Correlate with Long-Term Cardiovascular Outcome in Heart Failure Patients2025 · 1 citations