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April 29, 2026Colorectal Disease0 citations

The Garg phenomenon in supralevator anal fistulas: Avoiding overtreatment of the additional supralevator rectal opening to preserve continence

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NCNicola ClementeAHAbdallah HmittiJKJames C. W. Khaw

Key Points

  • This research addresses the management of supralevator anal fistulas and the implications of the Garg phenomenon on surgical practice.
  • Reviewed the ASGIIFT technique for intersphincteric management and sphincter preservation
  • Explored historical approaches to managing additional supralevator rectal openings
  • Analyzed results of three surgical strategies applied to ASRO during fistula surgery.
  • Fistulas healed successfully regardless of the ASRO management strategy employed
  • Demonstrated the Garg phenomenon, where treating primary openings promotes healing of secondary openings
  • Management strategies can avoid unnecessary high rectal dissections.

Abstract

We read with great interest Karlović et al.'s article detailing the ASGIIFT technique 1, which rightly emphasizes intersphincteric management and sphincter preservation. Building upon this vital discourse, we highlight a specific anatomical scenario where avoiding overtreatment is equally paramount: the supralevator fistula-in-ano presenting with an additional supralevator rectal opening (ASRO). Supralevator fistulas are formidable challenges requiring precise preoperative magnetic resonance imaging mapping 2. Historically, addressing an ASRO—a secondary high rectal opening situated above the primary internal opening at the dentate line—carried catastrophic risks to continence mechanisms and pelvic floor integrity. Prior to recent research, no definitive guidelines directed ASRO management 2. The first comparative study addressing this was conducted by Garg et al. in 2021 3. The ASRO was managed via three intraoperative strategies: laying open into the rectum, mucosal cauterization or leaving it entirely untreated. Remarkably, fistulas healed successfully regardless of the ASRO strategy. The clinical observation—once the primary internal opening at the dentate line is adequately managed, then leaving the ASRO completely untreated does not compromise ultimate healing—is aptly termed the ‘Garg phenomenon’ 4. This phenomenon aligns seamlessly with classic cryptoglandular theory 5. Once the primary infected anal gland at the dentate line is eradicated, halting the influx of sepsis, the secondary high supralevator tract loses its infective drive and heals spontaneously 5. In modern sphincter-preserving surgery, the ‘Garg phenomenon’ represents a vital paradigm shift. By understanding that the ASRO heals spontaneously once the primary opening is addressed, colorectal surgeons can confidently avoid perilous high rectal dissections. Applying the ‘Garg phenomenon’ prevents unnecessary surgical morbidity and secures long-term continence. Nicola Clemente: Conceptualization; writing – review and editing; project administration; software; methodology; validation; supervision. Abdallah Hmitti: Conceptualization; writing – review and editing; investigation; validation; methodology; software; supervision; data curation. James C. W. Khaw: Conceptualization; writing – original draft; writing – review and editing; project administration; formal analysis; methodology; data curation; investigation. The authors have nothing to report. The authors have nothing to report. None reported. No patient or patient data involved. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

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Cite This Study

Clemente et al. (2026) studied this question.

synapsesocial.com/papers/69f154e0879cb923c4945185https://doi.org/10.1111/codi.70465
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autologous skin graft intersphincteric implantation in anal fistula treatment ( ASGIIFT ) – A novel surgical technique in the treatment of complex transsphincteric anal fistulas2026 · 1 citations
  2. 2A classification of fistula-in-ano1976 · 1,659 citations
  3. 3TROPIS is effective in managing complex anal fistulas with additional supralevator rectal opening (ASRO) by Garg phenomenon2025 · 1 citations
  4. 4Comparison of MRI and Endoanal Ultrasound in Assessing Intersphincteric, Transsphincteric, and Suprasphincteric Perianal Fistula2023 · 33 citations
  5. 5Surgery of the Anus, Rectum and Colon1976 · 1,618 citations