Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population

Daeeun Kim; Hannah G. Polikowsky; Heather M. Highland; Hung-Hsin Chen; Wanying Zhu; Xinruo Zhang; Madeline G Gillman; Eitan Frankel; Rashedeh Roshani; Joshua M. Landman; Yujie Wang; Kristin L. Young; Mohammad Yaser Anwar; Mohanraj Krishnan; Victoria L Buchanan; Sonja I. Berndt; Joshua Arias; Laura M. Raffield; ABSALON D. GUTIERREZ; Faraz Bishehsari; Miryoung Lee; Joseph B. McCormick; Susan P. Fisher-Hoch; Jennifer E. Below; Kari E. North; Mariaelisa Graff

doi:10.1161/circgen.125.005298

Key Points

To explore the genetic and transcriptomic factors influencing obesity in a high-risk Hispanic/Latino population.
Utilized genome-wide association studies to identify obesity loci.
Performed expression quantitative trait loci mapping to assess gene expression.
Conducted colocalization analyses of GWAS and expression quantitative trait loci.
Identified MAPK11 and PER1 as significant obesity susceptibility genes.
Established links between identified genes and body mass index in females.
Highlighted the genes' roles in pathways related to inflammation and circadian rhythm.

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Implication

Integrative analysis uncovers key roles of PER1 and obesity genes in high-risk Hispanic/Latino individuals, suggesting genetic impacts on body mass index and inflammation.

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69f154f9879cb923c49453db https://doi.org/10.1161/circgen.125.005298

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Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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