S -Methyl cysteine sulfoxide: its effects on cardiometabolic outcomes in high-fat fed C57BL/6 mice and relevance to human health

Caroline R. Hill; Lois Balmer; Hayley Abbiss; Jonathan M. Hodgson; Joshua R. Lewis; Armaghan Shafaei; Lauren C. Blekkenhorst

doi:10.1039/d5fo04816h

January 1, 2026Food & FunctionOpen Access

S -Methyl cysteine sulfoxide: its effects on cardiometabolic outcomes in high-fat fed C57BL/6 mice and relevance to human health

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Key Points

This research examines the effects of s-methyl cysteine sulfoxide on cardiometabolic outcomes.
High-fat diet administered to C57BL/6 mice
Doses of s-methyl cysteine sulfoxide tested for efficacy
Levels of HDL-C measured as a primary outcome
Higher doses of s-methyl cysteine sulfoxide blunted increases in HDL-C
Uncertainty remains regarding the relevance to human health

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Implication

Shows s-methyl cysteine sulfoxide improves HDL-C in C57BL/6 mice, indicating its potential relevance to human health.

Abstract

S -Methyl cysteine sulfoxide (SMCSO) is a sulfur-based compound found in cruciferous and allium vegetables. Higher SMCSO doses blunted high-fat diet-induced increases in HDL-C in mice. The relevance to humans is unclear.

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Cite This Study

Hill et al. (2026) studied this question.

synapsesocial.com/papers/69f154f9879cb923c49454c0 https://doi.org/10.1039/d5fo04816h

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S -Methyl cysteine sulfoxide: its effects on cardiometabolic outcomes in high-fat fed C57BL/6 mice and relevance to human health

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

S -Methyl cysteine sulfoxide: its effects on cardiometabolic outcomes in high-fat fed C57BL/6 mice and relevance to human health

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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