Why the study?
Do glucose fluctuations increase cardiac fibrosis and the incidence of atrial fibrillation in diabetic rats?
Do glucose fluctuations increase cardiac fibrosis and the incidence of atrial fibrillation in diabetic rats?
Glucose fluctuations exacerbate cardiac fibrosis and increase atrial fibrillation inducibility in diabetic rats, potentially via Txnip-mediated oxidative stress and apoptosis.
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Should not alter glycemic targets in diabetes; hypothesis-generating for glucose fluctuations promoting AF via fibrosis in humans.
Saito et al. (2014) studied this question.
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