Long-term clinical progression of Sneddon syndrome associated with antiphospholipid syndrome.

Sneddon syndrome (SS) is a rare neurocutaneous disorder characterized by livedo racemosa and recurrent cerebrovascular events, frequently associated with antiphospholipid syndrome (APS). We report a 10-year follow-up of a 62-year-old man diagnosed with SS and APS. Initial presentation included seizures and ischemic lesions on brain magnetic resonance imaging (MRI). Over the years, he developed progressive livedo racemosa, progression of ischemic brain lesions, and cognitive decline. This case illustrates the natural course of SS, despite adequate therapy.