Clinical Efficacy and Scalp Microbiome Changes Induced by AMPamide-Containing Shampoo in Patients With Seborrheic Dermatitis

Background: Seborrheic dermatitis (SD) is a chronic inflammatory scalp disorder associated with Malassezia dysbiosis and increased sebum production.AMPamide has been suggested to have anti-inflammatory and sebum-regulating effects, but its clinical efficacy and microbiome-modulating effects in SD remain unclear.Objective: To evaluate the clinical efficacy and scalp microbiome changes following 4 weeks of use of an AMPamide-containing shampoo in patients with SD.Methods: In this observational study, 30 patients with SD applied an AMPamide-containing shampoo for 4 consecutive weeks.Clinical outcomes, including sebum levels and overall severity scores, were assessed.Scalp bacterial and fungal communities were analyzed to evaluate and -diversity and changes in Malassezia composition.Results: Treatment resulted in significant reductions in sebum levels and clinical severity scores, particularly in erythema, dandruff, and pruritus.Bacterial community composition remained largely stable, while fungal -diversity increased, and -diversity analysis revealed a decrease in the ratio of Malassezia restricta to Malassezia globosa.Conclusion: AMPamide-containing shampoo was associated with improved clinical symptoms and a shift toward a more balanced fungal community composition in patients with SD, supporting its potential as a non-steroidal therapeutic option for SD.