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April 1, 2026JHLT OpenOpen Access

Comparison of donor derived cell free DNA fractions between combined heart-lung vs isolated heart or lung transplant recipients

Shravani Pasupneti Vincent Valentine Hannah Mudgett Chun-Po Steve Fan Emerald Mann Mingming Zhou Ling Shen Erik Henricksen Kiran Khush Paul Hanson JW MacArthur Deborah Levine Gundeep Dhillon

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Key Points

This study aims to compare donor derived cell free DNA profiles between heart-lung and isolated heart or lung transplant recipients.
Screened HLTx recipients at a single center from August 2022 to September 2024.
Collected plasma dd-cfDNA samples before bronchoscopies and evaluations for graft dysfunction.
Monitored pulmonary function tests over the first-year post-transplant.
HLTx recipients had a median dd-cfDNA of 0.14, significantly lower than LTx (0.34) and HTx (0.06) with p<0.001.
31% of HLTx patients were unstable one year post-transplant compared to 84% for LTx.
Acute rejection rates were 10% for HLTx, 10.5% for HTx, and 22.3% for LTx.

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Implication

Compares dd-cfDNA levels in heart-lung and heart or lung transplant recipients, suggesting new monitoring methods.

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Cite This Study

Pasupneti et al. (2026) studied this question.

synapsesocial.com/papers/69f19f74edf4b4682480633b https://doi.org/10.1016/j.jhlto.2026.100569

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Donor-derived cell-free DNA is a valuable monitoring tool after single lung transplantation: Multicenter analysis2024 · 6 citations
2Donor-Derived Cell-Free DNA as a Prognostic Biomarker After Heart Transplantationcohort · 2026 · 4 citations
3Donor-derived cell-free DNA levels predict graft injury in liver transplant recipientsOriginal Research · 2021 · 101 citations
4Donor-derived cell-free DNA, gene expression profile, and acute rejection in donation after circulatory death (DCD) heart transplant recipients2024 · 2 citations
5Early Post-Transplant Recipient Tissue Injury Predicts Allograft Function, Rejection, and Survival in Lung Transplant Recipients, Evidence from Cell-free DNA2025 · 8 citations

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Significance of Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients With Negative Endomyocardial Biopsies: A Dawn of a New Era2025

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