Deferoxamine Attenuates Early Brain Injury After Subarachnoid Hemorrhage by Inhibiting Ferroptosis and Preserving Mitochondrial Function and Oxidative Phosphorylation via Nrf2 Signaling

Guodong Liu; Wen Shan; Zhiyuan Zhang; Wuting Wei; Yu Wei; Wanshan Bai; Jing Dai; 林毅兴

doi:10.1016/j.jstrokecerebrovasdis.2026.108644

April 1, 2026Journal of Stroke and Cerebrovascular DiseasesOpen Access

Deferoxamine Attenuates Early Brain Injury After Subarachnoid Hemorrhage by Inhibiting Ferroptosis and Preserving Mitochondrial Function and Oxidative Phosphorylation via Nrf2 Signaling

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to evaluate the protective effects of deferoxamine on early brain injury following subarachnoid hemorrhage.
Evaluated the effects of deferoxamine on brain injury after subarachnoid hemorrhage.
Assessed mitochondrial dynamics, morphology, and ATP production alongside neurological function.
Monitored blood-brain barrier disruption and brain edema as secondary outcomes.
Deferoxamine significantly inhibits ferroptosis, leading to reduced brain injury.
Improved mitochondrial function resulted in better ATP production and preserved neuronal health.
Deferoxamine reduced blood-brain barrier disruption and brain edema while enhancing neurological function.

Implication

Demonstrates improved neurological function in subarachnoid hemorrhage, suggesting therapeutic potential.

Abstract

DFO attenuates early brain injury after SAH by inhibiting ferroptosis. DFO preserves mitochondrial dynamics, morphology, and ATP production. DFO reduces BBB disruption, brain edema, and improves neurological function

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69f19f74edf4b46824806383 https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108644

View Full Paper

Ask AI

Bookmark

Share

Deferoxamine Attenuates Early Brain Injury After Subarachnoid Hemorrhage by Inhibiting Ferroptosis and Preserving Mitochondrial Function and Oxidative Phosphorylation via Nrf2 Signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

Deferoxamine Attenuates Early Brain Injury After Subarachnoid Hemorrhage by Inhibiting Ferroptosis and Preserving Mitochondrial Function and Oxidative Phosphorylation via Nrf2 Signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading