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April 27, 2026Recent trends in pharmacology.Open Access

Betulinic Acid Mitigates Estrogen Deficiency–Related Femoral Bone Loss: Evidence from an Ovariectomized Rat Model

Onural Özhan Hilal Şahin Mehmet Fatih Korkmaz Azibe Yıldız Ersoy Kekilli Nigar Vardı Hakan Parlakpınar

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Key Points

This study aims to assess the effects of betulinic acid on bone health in an ovariectomized rat model, focusing on estrogen deficiency-related bone loss.
Thirty-two female Wistar albino rats were randomly assigned to Sham, OVX, BA+OVX, and OVX+BA groups (n=8 each).
Betulinic acid was administered orally at a dose of 3 mg/kg/day.
Pelvic bone mineral density was measured using dual-energy X-ray absorptiometry (DEXA) and histopathological evaluations were conducted on femoral bone tissue.
OVX significantly reduced pelvic bone mineral density and deteriorated trabecular architecture compared to the Sham group.
BA administered before OVX significantly preserved pelvic bone mineral density and trabecular structure compared to the OVX group.

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Implication

Demonstrates the impact of betulinic acid on bone loss in ovariectomized rats, highlighting its potential protective properties.

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Cite This Study

Özhan et al. (2026) studied this question.

synapsesocial.com/papers/69f19f9cedf4b468248065d5 https://doi.org/10.62425/rtpharma.1871984

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Sodium Phenylbutyrate Ameliorates Ovariectomy-Induced Bone Loss in Rats2025
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