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April 27, 2026Journal of Agricultural and Food Chemistry

Elucidating the Biosynthetic Pathway of Lactone-Type Spirotetronate Polyketide PA-46101s with Inhibitory Activities against Aquatic Pathogenic Bacteria

Li-Li Hong Yijia Cheng Wenyu Zhang Jiaming Luo Fan Yang Cui-Xian Zhang Hou-Wen Lin Y Zhou

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Key Points

The aim is to elucidate the biosynthetic pathway of PA-46101s to enhance structural diversity.
Utilized combinatorial biology techniques for pathway elucidation.
Focused on the structural properties of PA-46101s.
Identified key components of the biosynthetic pathway.
Showed potential for structural diversification of PA-46101s.

Implication

Research uncovers the biosynthetic pathway of PA-46101s, indicating potential to combat aquatic pathogens.

Abstract

. This study paves the way for the structural diversification of PA-46101s through combinatorial biology.

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69f19f9cedf4b46824806677 https://doi.org/10.1021/acs.jafc.5c16909

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