Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa : design, synthesis, biological evaluation, and biofilm inhibition

Kosana Sai Chaitanya; Tsz Tin Yu; Hrushikesh Chaudhari; Nidhi Orenkonday; Pranali V. Kuthe; N Di Girolamo RK Kumar; Ruchi Jain Dey; Sankaranarayanan Murugesan; Kondapalli Venkata Gowri Chandra Sekhar

doi:10.1039/d6ra00717a

January 1, 2026RSC AdvancesOpen Access

Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa : design, synthesis, biological evaluation, and biofilm inhibition

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Key Points

This research aims to discover and evaluate thiolactone-based triazole derivatives as inhibitors of quorum sensing in Pseudomonas aeruginosa.
Synthetic methodology applied to create thiolactone-based compounds targeting LasR.
Biological evaluation testing the effectiveness of compounds 10o and 11b in inhibiting biofilm formation.
Compounds 10o and 11b exhibited significant biofilm inhibition in Pseudomonas aeruginosa.
Strength of biofilm inhibition was notably effective compared to control, demonstrating their potential as therapeutic agents.

Implication

Evaluates biofilm inhibition by thiolactone-based triazole hybrids in Pseudomonas aeruginosa, indicating potential therapeutic strategies.

Abstract

Quorum sensing regulates biofilm, virulence and resistance in bacteria. Thiolactone-based 1,2,3-triazole hybrids were synthesized as LasR-targeting inhibitors against Pseudomonas aeruginosa . Compounds 10o and 11b showed strong biofilm inhibition.

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Cite This Study

Chaitanya et al. (2026) studied this question.

synapsesocial.com/papers/6a1295f648a0ea166567263a https://doi.org/10.1039/d6ra00717a

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Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa : design, synthesis, biological evaluation, and biofilm inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa : design, synthesis, biological evaluation, and biofilm inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

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