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April 29, 2026ACS Applied Materials & Interfaces2 citationsOpen Access

Combinatorial Design of Slippery, Nitric Oxide-Releasing Surfaces Incorporating Copper Nanoparticles for Blood-Contacting Devices

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VPVicente PinonMGMark GarrenYWYi Xi Wu

Key Points

  • The research aims to create multifunctional medical device surfaces that reduce bacterial growth and prevent blood-related complications.
  • Integrated nitric oxide-releasing silicone rubber with copper nanoparticles and a liquid-infused layer.
  • Evaluated bacterial cell viability, blood protein adsorption, and platelet activation.
  • Achieved >99.8% reduction in bacterial cell viability and 98.7% in another strain.
  • Reduced blood protein adsorption by >80% and prevented platelet activation by >72%.

Abstract

with >99.8% and 98.7% reduction in bacterial cell viability, respectively. In addition, LI reduced blood protein adsorption by >80% and prevented platelet activation by >72%. By integrating nitric oxide-releasing silicone rubber with copper nanoparticles and a liquid-infused layer, these surface modifications produce a multifunctional medical device surface with antibacterial, antithrombotic, and antifouling capabilities.

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Cite This Study

Pinon et al. (2026) studied this question.

synapsesocial.com/papers/69f19ff5edf4b46824806947https://doi.org/10.1021/acsami.6c02385
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