Multisystem inflammatory syndrome in children (MIS-C), United States, 2023–2024

Q: What does this research mean for the field?

In 2023-2024, the clinical presentation of MIS-C remained largely unchanged from previous years, and 99% of cases among vaccine-eligible children occurred in those who were not up-to-date with their COVID-19 vaccinations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ami B. Shah; Katherine Lindsey; Laura D. Zambrano; Rebecca J. Free; Regina M. Simeone; Angela P Campbell; Anna R Yousaf; the MIS-C Surveillance Authorship Group; Xandy Peterson Pompa; Haytham Safi; Adrianna Stanley-Downs; Deva Borthwick; Jacqueline Denning; Tiffany White; Gabrielle Williams; Walaa Elbedewy; Anjali Vyas; K. Turner; Megan Crutchfield; Mallory Sinner; Stacy Davidson; G. V. Richardson; Julie Hand; Chloe Manchester; Anna Krueger; Juliana Jacoboski Duncan; Libby Reeg; Cole Burkholder; Paige D’Heilly; Sarah Lim; Theresa Kittle; Alexandra Berkley; Jessica Goswitz; Hannah Ball; Sai Paritala; Saadiah Khan; Nagla Bayoumi; Christopher Gil; Donna Gowie; Ty Lautenschlager; Jeremy Budd; Allison Longenberger; Carmen J Rodriguez Caquias; Andrew Torres; Abby L. Berns; Karen Luther; LaKita D Johnson; Hani Mohamed; Amanda Hartley; Danita Crear; TaKindra Westbrook; Amanda Dodd; Johanna Bosse

doi:10.1093/cid/ciag259

April 24, 2026Clinical Infectious Diseases

Multisystem inflammatory syndrome in children (MIS-C), United States, 2023–2024

View at Publisher

Ask AI

Bookmark

Share

Key Points

To analyze the incidence and clinical characteristics of MIS-C in children in the U.S. between 2023 and 2024.
Case analysis of MIS-C reported in children from 2023-2024
Focus on vaccination status among cases
Comparison of clinical presentation between years
99% of MIS-C cases occurred in unvaccinated children eligible for COVID-19 vaccination
No significant changes in clinical presentation of MIS-C cases from prior years

Implication

Analysis reveals persistent clinical features of MIS-C in unvaccinated children during recent outbreaks.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is rare following SARS-CoV-2 infection, but sporadic cases continue to be reported. This analysis of cases from 2023-2024 shows little change in clinical presentation between years. Among vaccine age-eligible children, 99% of cases occurred in children who were not up-to-date with COVID-19 vaccination.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shah et al. (2026) studied this question.

synapsesocial.com/papers/69f1a08eedf4b468248070f5 https://doi.org/10.1093/cid/ciag259

View at Publisher

Ask AI

Bookmark

Share

Multisystem inflammatory syndrome in children (MIS-C), United States, 2023–2024

Key Points

Implication

Abstract

Discussion

Cite This Study

Multisystem inflammatory syndrome in children (MIS-C), United States, 2023–2024

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading