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Develops a method for predicting dissolution in modified-release carbamazepine formulations, indicating improved bioequivalence assessment.
prediction errors of -6.09% and -1.94%, respectively. The method effectively distinguished IR from MR formulations, with discriminatory analysis (f1, f2, DE, MDT) confirming its sensitivity. A predictive flow-through cell dissolution method was successfully developed, providing a robust tool for bioequivalence studies and generic formulation development. This approach supports formulation optimization and increases the likelihood of successful in vivo bioequivalence outcomes.
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Barbosa et al. (2026) studied this question.
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