Overview reveals maternal immune correlates of vertical transmission in primary cytomegalovirus pregnancy, indicating potential vaccine targets despite marked individual variability.
T cells) were significantly associated with vertical transmission. This overview provides important information at the population level, which may help to inform the evaluation of interventions such as vaccination or treatments designed to interrupt intrauterine transmission of HCMV during primary infection. However, although we are waiting for an HCMV vaccination to become available, we emphasize that none of these parameters can be prognostically used on an individual basis because of the great variation in values among women.
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Lilleri et al. (2016) studied this question.
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