April 1, 1995AnesthesiologyOpen Access

Propofol Has No Direct Effect on Sinoatrial Node Function or on Normal Atrioventricular and Accessory Pathway Conduction in Wolff-Parkinson-White Syndrome during Alfentanil/Midazolam Anesthesia

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Why the study?

Does propofol alter electrophysiologic properties of the SA node, AV node, and accessory pathways in patients with Wolff-Parkinson-White syndrome undergoing ablation?

Population

12 patients with Wolff-Parkinson-White syndrome undergoing radiofrequency catheter ablation

Comparison

Propofol administered after discontinuation of… vs Baseline electrophysiologic measurements during…

Design

Cohort

Follow-up

intraoperative

Authors

MSMichael D. SharpeWestern University WDWojciech B. DobkowskiWestern University JMJohn M. MurkinWestern University

Discussion

Member takes

Implication

Propofol may suit anesthesia in WPW ablation; observational data leaves open randomized confirmation before practice change.

Structured PICO

Does propofol alter electrophysiologic properties of the SA node, AV node, and accessory pathways in patients with Wolff-Parkinson-White syndrome undergoing ablation?

Population

12 patients with Wolff-Parkinson-White syndrome undergoing radiofrequency catheter ablation

Intervention

Propofol (bolus 2 mg/kg + 120 micrograms.kg-1.min-1) administered after discontinuation of alfentanil/midazolam

Comparator

Baseline electrophysiologic measurements during alfentanil/midazolam anesthesia

Outcome

Electrophysiologic properties including effective refractory period of the right atrium, AV node, and accessory pathway, shortest cycle length, and SA node function parameters (sinus node recovery time, corrected sinus node recovery time, SA conduction time)surrogate

Propofol does not significantly alter SA node function or AV/accessory pathway conduction, making it a suitable anesthetic for patients with Wolff-Parkinson-White syndrome undergoing ablation.

Cite This Study

Sharpe et al. (1995) studied this question.

synapsesocial.com/papers/69f1a129e7adab9d6a2a7cce https://doi.org/10.1097/00000542-199504000-00011

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Propofol Has No Direct Effect on Sinoatrial Node Function or on Normal Atrioventricular and Accessory Pathway Conduction in Wolff-Parkinson-White Syndrome during Alfentanil/Midazolam Anesthesia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Propofol Has No Direct Effect on Sinoatrial Node Function or on Normal Atrioventricular and Accessory Pathway Conduction in Wolff-Parkinson-White Syndrome during Alfentanil/Midazolam Anesthesia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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