Key result
Novel leadless pacemaker for conduction system pacing requires further evaluation of stability and fixation.
Why the study?
Following an acute pass-pull study demonstrating acute pacing of the deep interventricular septum, chronic performance of a novel leadless pacemaker for conduction system pacing needed evaluation.
Cohort
A first-in-human evaluation of a novel leadless pacemaker for conduction system pacing identified issues with dislodgements and dislocation, indicating stability fixation requires further evaluation.
Answers are grounded in this paper and cite their sources.
Early stability failures caution against clinical adoption; hypothesis-generating for leadless conduction system pacing feasibility.
BACKGROUND: In a first-in-human acute "pass-pull" study, we previously demonstrated that a novel leadless pacemaker (LP) for conduction system pacing (CSP) could acutely pace the deep interventricular septum (IVS). OBJECTIVE: . METHODS: was implanted under fluoroscopic and intra-cardiac echocardiography guidance. The primary safety end point was complications at 1-month. Electrical performance (capture threshold at 0.4 ms, R-wave amplitude, impedance) and capture type (left bundle branch pacing [LBBP] vs left ventricular septal pacing [LVSP] vs deep septal pacing [DSP]) were assessed at implant and at 1 month. RESULTS: dislodgements, and dislocation. CONCLUSION: stability fixation require further evaluation.
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Reddy et al. (2026) conducted a cohort in Conduction system pacing. Novel leadless pacemaker for conduction system pacing was evaluated on Complications at 1-month. A novel leadless pacemaker for conduction system pacing was evaluated, but stability and fixation require further evaluation.
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