Why the study?
Do individualized heart rate correction formulas improve the accuracy of assessing drug-induced QTc prolongation compared to published formulas in subjects receiving ebastine or terfenadine?
Do individualized heart rate correction formulas improve the accuracy of assessing drug-induced QTc prolongation compared to published formulas in subjects receiving ebastine or terfenadine?
Individualized heart rate correction formulas for each subject are superior to published or pooled formulas for accurately assessing drug-induced QTc prolongation.
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Individualized QT corrections should replace published formulas for drug-induced QTc assessment; confirms superiority in RCTs.
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Marek Malik (2001) studied this question.
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