Why the study?
Most clinical data and diagnostic thresholds for flow-based indexes derive from Doppler measurements, leaving correspondence with thermodilution-derived indices unclear.
How do thermodilution-derived indexes of coronary physiology compare to Doppler flow velocity-derived indexes in patients undergoing coronary flow measurements?
Population
Patients with coronary flow measurements using Doppler and thermodilution techniques in the same vessel and procedure
Comparison
Doppler flow velocity vs thermodilution-derived indexes
Design
International multicenter registry
Authors
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Thermodilution CFR threshold <2.5 may better match Doppler accuracy; resistance index correlations remain weak and require validation.
How do thermodilution-derived indexes of coronary physiology compare to Doppler flow velocity-derived indexes in patients undergoing coronary flow measurements?
Thermodilution-derived CFR using a threshold of <2.5 yields reasonable diagnostic accuracy compared to Doppler, though microvascular resistance indexes correlate weakly between the two modalities.
Demir et al. (2022) studied this question.
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