April 29, 2026Journal of the American College of Cardiology
Assessment of Left Ventricular Dyssynchrony by Speckle Tracking Strain Imaging
Key result
Baseline radial strain dyssynchrony ≥130 ms strongly predicts a positive response to CRT.
- P<0.001
- n=161
Why the study?
Multiple echocardiographic techniques exist for LV dyssynchrony, but the utility of 2D speckle tracking strain types to assess dyssynchrony and predict CRT response remained to be evaluated.
Population
161 patients undergoing CRT
Comparison
Radial vs circumferential vs longitudinal strain
Design
Observational study
Follow-up
6 months
Authors
Discussion
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Implication
Radial strain dyssynchrony may identify CRT responders; leaves open its incremental value pending randomized validation.
Study Design
Type
Observational (n=161)
PICO
P
Population
Patients undergoing cardiac resynchronization therapy (CRT) (n=161)
I
Intervention / Comparator
2D speckle tracking radial strain analysis vs Circumferential and longitudinal strain / Nonresponders
O
Primary Outcome
Response to CRT (decrease in LV end-systolic volume ≥15% at follow-up), p=<0.001
Main Result
p-value: p=<0.001
Cite This Study
Delgado et al. (2008) conducted an observational in Patients undergoing cardiac resynchronization therapy (CRT) (n=161). 2D speckle tracking radial strain analysis vs. Circumferential and longitudinal strain / Nonresponders was evaluated on Response to CRT (decrease in LV end-systolic volume ≥15% at follow-up) (p=<0.001). Baseline radial strain dyssynchrony ≥130 ms predicted a positive response to cardiac resynchronization therapy with 83% sensitivity and 80% specificity.