What question did this study set out to answer?

To determine whether human circadian rhythm timing and amplitude differ by sex when controlling for environmental and behavioral masking effects using a constant routine protocol.

August 1, 2010Journal of Biological Rhythms

Sex Differences in Phase Angle of Entrainment and Melatonin Amplitude in Humans

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To determine whether human circadian rhythm timing and amplitude differ by sex when controlling for environmental and behavioral masking effects using a constant routine protocol.
Studied 56 healthy young adults (28 women and 28 men paired by habitual wake time; age range: 18–30 years) who maintained a regular self-selected sleep-wake schedule before entering the laboratory.
Conducted a 3-day baseline evaluation followed by an unmasking constant routine protocol to assess endogenous circadian rhythms of core body temperature and pineal melatonin secretion.
Women exhibited significantly higher melatonin amplitude and lower core body temperature amplitude compared to men.
Circadian rhythms of core body temperature and pineal melatonin secretion were phased significantly earlier relative to habitual sleep time in women.
Sleep occurred at a later biological time in women than men despite identical behavioral sleep timing.

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Implication

Controlled laboratory study demonstrates earlier circadian phase timing and higher melatonin amplitude in women compared with men, suggesting biological drivers behind sex differences in sleep...

Cite This Study

Cain et al. (2010) studied this question.

synapsesocial.com/papers/69f24b2efdff1de28dabc3d8 https://doi.org/10.1177/0748730410374943

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Implication

Controlled laboratory study demonstrates earlier circadian phase timing and higher melatonin amplitude in women compared with men, suggesting biological drivers behind sex differences in sleep...

Sex Differences in Phase Angle of Entrainment and Melatonin Amplitude in Humans

Key Points

Discussion

Implication

Cite This Study

Sex Differences in Phase Angle of Entrainment and Melatonin Amplitude in Humans

Key Points

Discussion

Implication

Cite This Study

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