Why the study?
Does atrial fibrillation increase inflammatory markers and fibrosis in the atrial myocardium of patients with valvular disease compared to sinus rhythm?
Population
Patients with valvular disease undergoing surgery with extracorporeal circulation, presenting with either…
Comparison
Atrial fibrillation (AF) vs Sinus rhythm (SR)
Design
Cross-sectional
Authors
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Supports inflammatory role in valvular AF; leaves open causality and whether targeting inflammation improves outcomes.
Does atrial fibrillation increase inflammatory markers and fibrosis in the atrial myocardium of patients with valvular disease compared to sinus rhythm?
Atrial fibrillation in patients with valvular disease is associated with increased local myocardial inflammation and fibrosis, suggesting an inflammatory component in its pathophysiology.
Qu et al. (2009) studied this question.
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