Key result
Atorvastatin reduces induced AF duration by ~67% in sterile pericarditis.
Why the study?
The effect of statin therapy on atrial fibrillation associated with tissue inflammation was unclear.
Does atorvastatin reduce atrial fibrillation duration and inflammation in a canine sterile pericarditis model?
Population
20 dogs with sterile pericarditis model
Comparison
Atorvastatin 2 mg/kg/day orally vs control
Design
Randomized controlled preclinical study
Follow-up
2 days post-operation
Authors
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Atorvastatin attenuated postoperative AF in this model but should not change practice; leaves open anti-inflammatory benefits in human AF.
RCT (n=20)
randomly assigned
Does atorvastatin reduce atrial fibrillation duration and inflammation in a canine sterile pericarditis model?
Absolute Event Rate: 177% vs 534%
p-value: p=<0.0001
Atorvastatin reduces inflammation and prevents the maintenance of atrial fibrillation in a canine sterile pericarditis model, suggesting a potential therapeutic role for statins in AF.
Koichiro Kumagai (2004) conducted an RCT in Atrial fibrillation (n=20). Atorvastatin vs. Control was evaluated on Duration of induced AF (s) (p=<0.0001). Atorvastatin significantly reduced the duration of induced atrial fibrillation compared to control (177 vs 534 s; P<0.0001) in a canine sterile pericarditis model.
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