Application of the response surface methodology in the optimization of modified molecularly imprinted polymer based pipette-tip micro-solid phase extraction for spectrophotometric determination of nicotine in seawater and human plasma

In this paper, a novel molecularly imprinted polymer/zinc oxide (MIP/ZnO) was synthesized and applied as an adsorbent for pipette-tip micro-solid phase extraction (MIP/ZnO PT-μSPE) of nicotine from seawater and human plasma followed by its spectrophotometric detection.