August 21, 2007Circulation
Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress
Why the study?
Are visceral and subcutaneous adipose tissue volumes associated with markers of inflammation and oxidative stress in adults?
Population
1250 Framingham Heart Study participants (52% women; age 60+/-9 years)
Comparison
Visceral adipose tissue and subcutaneous adipose… vs Comparison between SAT and VAT
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
VAT may disproportionately drive oxidative stress versus SAT; leaves open causal roles and need for longitudinal confirmation.
Structured PICO
Are visceral and subcutaneous adipose tissue volumes associated with markers of inflammation and oxidative stress in adults?
P
Population
1250 Framingham Heart Study participants (52% women; age 60+/-9 years)
I
Intervention
Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes assessed by multidetector computerized tomography
C
Comparator
Comparison between SAT and VAT
O
Outcome
Circulating inflammatory and oxidative stress biomarkers (C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, P-selectin, tumor necrosis factor receptor-2, urinary isoprostanes, and monocyte chemoattractant protein-1)surrogate
Both subcutaneous and visceral adipose tissue are associated with inflammation and oxidative stress, but the contribution of visceral fat is not completely accounted for by clinical measures of obesity like BMI and waist circumference.
Cite This Study
Pou et al. (2007) studied this question.