Why the study?
Is transcardiac serotonin concentration increased in patients with limiting angina and complex coronary lesion morphology compared to those without significant coronary artery disease?
Population
52 patients, including 39 with coronary artery disease and severe, limiting angina, and 13 with minimal or…
Comparison
Measurement of central aortic and coronary sinus… vs Patients with minimal or no coronary artery…
Design
Cross-sectional
Authors
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Serotonin release associated with complex CAD lesions; hypothesis-generating for unstable syndromes and requires prospective confirmation.
Is transcardiac serotonin concentration increased in patients with limiting angina and complex coronary lesion morphology compared to those without significant coronary artery disease?
Serotonin is released into the coronary circulation in some patients with CAD, particularly those with frequent angina and complex coronary lesions, suggesting a potential pathophysiologic role in unstable ischemic syndromes.
Berg et al. (1989) studied this question.