Why the study?
Does TRPM4 deletion alter the inotropic effect of beta-adrenergic stimulation on ventricular heart muscle in mice?
Population
Trpm4 knockout (Trpm4-/-) mice and isolated ventricular myocytes
Comparison
Trpm4 gene deletion vs Wild-type controls (implied)
Design
Preclinical
Authors
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TRPM4 deletion augments beta-adrenergic inotropy and shortens repolarization in mice; human relevance and therapeutic implications remain to be tested.
Does TRPM4 deletion alter the inotropic effect of beta-adrenergic stimulation on ventricular heart muscle in mice?
TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on ventricular heart muscle, with their deletion leading to increased inotropy and shortened action potential duration.
Mathar et al. (2013) studied this question.
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