March 1, 1995Circulation
Paradoxical Arterial Wall Shrinkage May Contribute to Luminal Narrowing of Human Atherosclerotic Femoral Arteries
Population
51 human femoral arteries (32 postmortem and 19 in vivo)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Wall shrinkage contributes to femoral stenosis beyond plaque; hypothesis-generating for remodeling-targeted therapies pending prospective data.
Structured PICO
P
Population
51 human femoral arteries (32 postmortem and 19 in vivo)
I
Intervention
Histological and 30-MHz intravascular ultrasound examination
O
Outcome
Correlation between relative internal elastic lamina (IEL) area and lumen area stenosis percentagesurrogate
Arterial wall shrinkage, rather than just plaque increase, contributes significantly to severe luminal narrowing in atherosclerotic human femoral arteries.
Cite This Study
Pasterkamp et al. (1995) studied this question.