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June 1, 1994CirculationOpen Access

Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound.

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Why the study?

Does progressive atherosclerosis cause focal compensatory enlargement in human superficial femoral arteries as assessed by intravascular ultrasound?

Population

20 patients undergoing peripheral vascular interventions, contributing 62 paired, adjacent normal and…

Comparison

Intravascular ultrasound morphological assessment vs Adjacent normal arterial segments within the…

Design

Cross-sectional

Authors

DLDouglas W. LosordoInterventional CardiologyKRKenneth RosenfieldInterventional CardiologyJKJenifer KaufmanTufts University

Discussion

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Implication

Supports focal compensatory enlargement in atherosclerotic femoral arteries; extends histologic data to in vivo IVUS but remains hypothesis-generating.

Structured PICO

Does progressive atherosclerosis cause focal compensatory enlargement in human superficial femoral arteries as assessed by intravascular ultrasound?

P
Population
20 patients undergoing peripheral vascular interventions, contributing 62 paired, adjacent normal and diseased sites in the superficial femoral arteries
I
Intervention
Intravascular ultrasound (IVUS) morphological assessment
C
Comparator
Adjacent normal arterial segments within the same patients
O
Outcome
Cross-sectional area of the arterial lumen, atherosclerotic plaque, and outer border of the arterysurrogate

In vivo intravascular ultrasound confirms that human superficial femoral arteries undergo focal compensatory enlargement in response to progressive atherosclerosis.

Cite This Study

Losordo et al. (1994) studied this question.

synapsesocial.com/papers/69f29cea1b51e2fbf01872dchttps://doi.org/10.1161/01.cir.89.6.2570
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Compensatory Enlargement of Human Atherosclerotic Coronary Arteries1987 · 3,632 citations
  2. 2Delineation of the Extent of Coronary Atherosclerosis by High-Frequency Epicardial Echocardiography1987 · 217 citations