January 1, 1994Circulation

Gamma-globulin treatment of acute myocarditis in the pediatric population.

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Why the study?

Does high-dose intravenous gamma-globulin improve left ventricular function and survival in children with acute myocarditis?

Population

46 children with presumed acute myocarditis (n=21 consecutive cases, n=25 historical controls)

Comparison

Intravenous gamma-globulin 2 g/kg over 24 hours… vs Anticongestive therapies alone

Design

Cohort

Follow-up

1 year

Authors

NDNancy DruckerUniversity of Vermont SCSteven D. ColanPediatric / Congenital Cardiology ALA B LewisBoston Children's Hospital

Discussion

Member takes

Implication

IVIG associated with better LV recovery in pediatric myocarditis; hypothesis-generating and requires RCTs before any practice change.

Structured PICO

Does high-dose intravenous gamma-globulin improve left ventricular function and survival in children with acute myocarditis?

Population

46 children with presumed acute myocarditis (n=21 consecutive cases, n=25 historical controls)

Intervention

Intravenous gamma-globulin (IVIG) 2 g/kg over 24 hours added to anticongestive therapies

Comparator

Anticongestive therapies alone (historical controls meeting identical eligibility criteria)

Outcome

Left ventricular function (left ventricular end-diastolic dimension and fractional shortening) assessed at 0 to 7 days, 1 to 3 weeks, 3 weeks to 3 months, 3 to 6 months, and 6 to 12 monthssurrogate

High-dose IVIG administration in pediatric acute myocarditis is associated with improved recovery of left ventricular function and a trend toward better 1-year survival compared to historical controls.

Cite This Study

Drucker et al. (1994) studied this question.

synapsesocial.com/papers/69f29d011b51e2fbf0187362 https://doi.org/10.1161/01.cir.89.1.252

Topics

Myocarditis

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