October 28, 2011Journal of Cardiovascular Electrophysiology
Atrial Fibrillation in Patients with Wolff–Parkinson–White Syndrome:
Why the study?
Are there differences in the electrophysiological properties of pulmonary veins between WPW patients with and without a history of atrial fibrillation?
Population
31 patients with Wolff-Parkinson-White syndrome, mean age 40 ± 15 years, 23 males. Divided into 16 patients…
Comparison
Electrophysiological study to measure pulmonary… vs WPW patients without a history of AF
Design
Cohort
Authors
Discussion
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Implication
Pulmonary veins may contribute to AF in WPW; leaves open whether targeted PV ablation improves outcomes.
Structured PICO
Are there differences in the electrophysiological properties of pulmonary veins between WPW patients with and without a history of atrial fibrillation?
P
Population
31 patients with Wolff-Parkinson-White (WPW) syndrome, mean age 40 ± 15 years, 23 males. Divided into 16 patients with a history of atrial fibrillation (AF) and 15 without AF (controls).
I
Intervention
Electrophysiological study (EPS) to measure pulmonary vein properties
C
Comparator
WPW patients without a history of AF
O
Outcome
Effective refractory periods (ERPs) of pulmonary veins and maximal veno-atrial conduction delaysurrogate
Patients with WPW syndrome and AF have shorter effective refractory periods and greater veno-atrial conduction delay in pulmonary veins, suggesting PVs play a role in AF development in this population.
Cite This Study
Derejko et al. (2011) studied this question.