Why the study?
Does salt depletion via chlorthalidone or severe salt restriction reduce left ventricular mass in patients with arterial hypertension?
Population
Patients with arterial hypertension, off medication and on a balanced diet without salt restriction for at…
Comparison
Chlorthalidone 25 mg/day or severe restriction… vs Alternative treatment.
Design
RCT, Randomly allocated to either the diuretic or low-salt regimen for 6 weeks…
Follow-up
12 weeks (6 weeks per crossover period)
Authors
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Supports chlorthalidone or salt restriction to regress LV mass in hypertension; confirms similar short-term efficacy in this RCT.
Does salt depletion via chlorthalidone or severe salt restriction reduce left ventricular mass in patients with arterial hypertension?
Salt depletion through either chlorthalidone or severe dietary salt restriction significantly reduces left ventricular mass and blood pressure in hypertensive patients within 6 weeks.
Ferrara et al. (1984) studied this question.
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