January 13, 2004JAMA
Coronary Artery Calcium Score Combined With Framingham Score for Risk Prediction in Asymptomatic Individuals
Why the study?
Does combining Coronary Artery Calcium Score (CACS) with Framingham Risk Score (FRS) improve risk prediction for nonfatal MI or CHD death in asymptomatic adults with coronary risk factors?
Population
1,312 asymptomatic adults with at least 1 coronary risk factor, excluding patients with diabetes, missing…
Comparison
Coronary artery calcium scoring via computed… vs Framingham Risk Score (FRS) alone or CACS alone
Design
Cohort
Follow-up
median 7.0 years
Authors
Discussion
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Member takes
Implication
May refine CHD risk stratification in FRS>10% patients; leaves open whether CACS integration improves outcomes.
Structured PICO
Does combining Coronary Artery Calcium Score (CACS) with Framingham Risk Score (FRS) improve risk prediction for nonfatal MI or CHD death in asymptomatic adults with coronary risk factors?
P
Population
1,312 asymptomatic adults (>45 years) with at least 1 coronary risk factor, excluding patients with diabetes, missing data, or a coronary event before CACS was performed.
I
Intervention
Coronary artery calcium scoring (CACS) via computed tomography (CT) combined with Framingham Risk Score (FRS)
C
Comparator
Framingham Risk Score (FRS) alone or CACS alone
O
Outcome
Composite of nonfatal myocardial infarction (MI) or CHD deathhard clinical
Adding Coronary Artery Calcium Score (CACS) to the Framingham Risk Score significantly improves the prediction of hard CHD events in asymptomatic adults, particularly for those at intermediate risk.
Cite This Study
Philip Greenland (2004) studied this question.