What question did this study set out to answer?

To assess the functional contribution of the left atrium to left ventricular performance in patients with remote myocardial infarction.

March 1, 1983Circulation

Importance of left atrial function in patients with myocardial infarction.

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Why the study?

Is left atrial contribution to left ventricular function increased in patients with remote myocardial infarction compared to normal subjects?

Population

Patients with remote myocardial infarction and normal subjects

Comparison

Simultaneous left atrial pressure recording and… vs Normal subjects

Design

Cross-sectional

Authors

YMYasuo MatsudaYao Tokushukai General Hospital YTY TomaYamaguchi University HOHiroshi OgawaKagoshima University

Discussion

Member takes

Implication

May indicate compensatory atrial augmentation in remote MI; hypothesis-generating and should not yet change practice.

Key Points

To assess the functional contribution of the left atrium to left ventricular performance in patients with remote myocardial infarction.
Obtained simultaneous left atrial pressure recordings and left atrial and ventricular cineangiograms using a catheter-tip micromanometer in patients with remote myocardial infarction and normal subjects.
Constructed left atrial pressure-volume loops to quantify active atrial emptying volume, left ventricular stroke volume, and left atrial stroke work.
The ratio of active atrial emptying to left ventricular stroke volume was significantly elevated in patients with myocardial infarction compared to normal subjects (42 ± 12% vs 29 ± 10%, p < 0.05).
Left atrial work was significantly higher in myocardial infarction patients than in normal subjects (1690 ± 717 vs 940 ± 426 mm Hg × ml, p < 0.05) and inversely correlated with left ventricular ejection fraction (γ = -0.5, p < 0.05).
Left atrial work correlated positively with active emptying ratio (γ = 0.72, p < 0.01) and pre-emptying atrial volume (γ = 0.82, p < 0.01).

Structured PICO

Is left atrial contribution to left ventricular function increased in patients with remote myocardial infarction compared to normal subjects?

Population

Patients with remote myocardial infarction and normal subjects

Intervention

Simultaneous left atrial pressure recording and left atrial and left ventricular cineangiograms with a catheter-tip micromanometer

Comparator

Normal subjects

Outcome

Left atrial function (ratio of active atrial emptying to left ventricular stroke volume, and left atrial work)surrogate

In patients with remote myocardial infarction, the left atrial contribution to left ventricular function is increased, likely due to the Frank-Starling mechanism.

Cite This Study

Matsuda et al. (1983) studied this question.

synapsesocial.com/papers/69f29d8151fe1e6e26efb829 https://doi.org/10.1161/01.cir.67.3.566

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Importance of left atrial function in patients with myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Importance of left atrial function in patients with myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider