Why the study?
How does acute graded mitral regurgitation affect the dynamic geometry and pressures of the left atrium and left ventricle in an open-chest dog model?
How does acute graded mitral regurgitation affect the dynamic geometry and pressures of the left atrium and left ventricle in an open-chest dog model?
Acute severe mitral regurgitation leads to significant left atrial and ventricular dilation with impaired atrial contraction, which can be partially reversed by afterload reduction and inotropic support.
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Acute severe MR impairs LA shortening in this canine model; leaves open translation to human chronic MR or therapy.
Sasayama et al. (1979) studied this question.